Utility of Magnetic Resonance contrast agents in routine cranial imaging. Case study of an evaluative method

Scientific studies that document the utility and value of MR imaging in routine clinical practice must differ from double-blind, randomized clinical trials. The case study in this article represents an effort to create pragmatic methods for these clinical environments. An independent, judicial panel reviewed blinded readings of unenhanced and enhanced MR images. This panel determined that Gd-DTPA enhancement improved the readings that were close enough for clinical purposes--called Diagnostic Merit. More importantly, clinical care was not disrupted, and statistically significant benefits were shown in routine practice. Such studies could lead to earlier reimbursement for useful imaging technologies. (February 1994)